Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
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چکیده
منابع مشابه
Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation
Surface expression and regulated endocytosis of glycine receptors (GlyRs) play a critical function in balancing neuronal excitability. SUMOylation (SUMO modification) is of critical importance for maintaining neuronal function in the central nervous system. Here we show that activation of kainate receptors (KARs) causes GlyR endocytosis in a calcium- and protein kinase C (PKC)-dependent manner,...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms5980